The preliminary entry list for the Daytona 500 features 40 cars and 39 drivers listed.
| No. | Driver | Sponsor | Make |
| 00 | Jeffrey Earnhardt | VRX Simulators | Chevrolet |
| 1 | Jamie McMurray | McDonald’s/Cessna | Chevrolet |
| 2 | Brad Keselowski | Discount Tire | Ford |
| 3 | Austin Dillon | Dow | Chevrolet |
| 4 | Kevin Harvick | Jimmy Johns | Ford |
| 6 | Trevor Bayne | AdvoCare | Ford |
| 7 | Danica Patrick | GoDaddy | Chevrolet |
| 9 | Chase Elliott | NAPA Auto Parts | Chevrolet |
| 10 | Aric Almirola | Smithfield | Ford |
| 11 | Denny Hamlin | FedEx Express | Toyota |
| 12 | Ryan Blaney | Menards/Peak | Ford |
| 13 | Ty Dillon | GEICO | Chevrolet |
| 14 | Clint Bowyer | Rush Truck Centers/Mobil 1 | Ford |
| 17 | Ricky Stenhouse Jr. | Fastenal | Ford |
| 18 | Kyle Busch | M&M’s | Toyota |
| 19 | Daniel Suarez | ARRIS | Toyota |
| 20 | Erik Jones | DeWalt | Toyota |
| 21 | Paul Menard | Omnicraft Auto Parts/Quick Lane | Ford |
| 22 | Joey Logano | Shell Pennzoil | Ford |
| 23 | TBA | TBD | Toyota |
| 24 | William Byron | Axalta | Chevrolet |
| 31 | Ryan Newman | Bass Pro Shops/Cabela’s | Chevrolet |
| 32 | Matt DiBenedetto | The Hurricane Heist | Ford |
| 34 | Michael McDowell | Love’s Travel Stops | Ford |
| 37 | Chris Buescher | Kleenex | Chevrolet |
| 38 | David Ragan | Speedco | Ford |
| 41 | Kurt Busch | Haas Automation/Monster Energy | Ford |
| 42 | Kyle Larson | Credit One Bank | Chevrolet |
| 43 | Darrell Wallace Jr. | Click n Close | Chevrolet |
| 47 | AJ Allmendinger | Kroger ClickList | Chevrolet |
| 48 | Jimmie Johnson | Lowe’s | Chevrolet |
| 51 | Justin Marks | Harry’s Shaving Products/Katerra | Chevrolet |
| 62 | Brendan Gaughan | Beard Oil Distributing/South Point | Chevrolet |
| 66 | Mark Thompson | Phoenix Air | Ford |
| 72 | Corey LaJoie | Schluter Systems | Chevrolet |
| 78 | Martin Truex Jr. | Bass Pro Shops/5-hour Energy | Toyota |
| 88 | Alex Bowman | Nationwide | Chevrolet |
| 92 | David Gilliland | Black’s Tire Service/Carquest | Ford |
| 95 | Kasey Kahne | Procore | Chevrolet |
| 96 | D.J. Kennington | Lordco/Castrol | Toyota |
