| Fin | Str | Car | Driver | Make | Laps | Pts | Status | Laps Led |
| 1 | 16 | 11 | Denny Hamlin | Toyota | 208 | 47 | Running | 12 |
| 2 | 26 | 18 | Kyle Busch | Toyota | 208 | 35 | Running | – |
| 3 | 20 | 4 | Kevin Harvick | Ford | 208 | 40 | Running | 10 |
| 4 | 8 | 2 | Brad Keselowski | Ford | 208 | 33 | Running | 7 |
| 5 | 13 | 20 | Erik Jones | Toyota | 208 | 39 | Running | 27 |
| 6 | 3 | 22 | Joey Logano | Ford | 208 | 39 | Running | 19 |
| 7 | 9 | 10 | Aric Almirola | Ford | 208 | 35 | Running | – |
| 8 | 37 | 48 | Jimmie Johnson | Chevrolet | 208 | 29 | Running | – |
| 9 | 7 | 21 | Matt DiBenedetto | Ford | 208 | 29 | Running | – |
| 10 | 15 | 19 | Martin Truex Jr. | Toyota | 208 | 44 | Running | 16 |
| 11 | 24 | 95 | Christopher Bell # | Toyota | 208 | 26 | Running | – |
| 12 | 34 | 24 | William Byron | Chevrolet | 208 | 30 | Running | – |
| 13 | 14 | 8 | Tyler Reddick # | Chevrolet | 208 | 24 | Running | – |
| 14 | 6 | 6 | Ryan Newman | Ford | 208 | 23 | Running | 5 |
| 15 | 18 | 1 | Kurt Busch | Chevrolet | 208 | 22 | Running | – |
| 16 | 21 | 43 | Bubba Wallace | Chevrolet | 208 | 21 | Running | 3 |
| 17 | 23 | 34 | Michael McDowell | Ford | 208 | 20 | Running | – |
| 18 | 19 | 88 | Alex Bowman | Chevrolet | 208 | 29 | Running | – |
| 19 | 2 | 13 | Ty Dillon | Chevrolet | 208 | 18 | Running | 8 |
| 20 | 10 | 3 | Austin Dillon | Chevrolet | 208 | 17 | Running | – |
| 21 | 5 | 12 | Ryan Blaney | Ford | 208 | 24 | Running | – |
| 22 | 4 | 14 | Clint Bowyer | Ford | 208 | 35 | Running | 71 |
| 23 | 32 | 17 | Chris Buescher | Ford | 208 | 14 | Running | – |
| 24 | 31 | 32 | Corey LaJoie | Ford | 207 | 13 | Running | – |
| 25 | 39 | 47 | Ricky Stenhouse Jr. | Chevrolet | 207 | 12 | Running | – |
| 26 | 35 | 00 | Quin Houff # | Chevrolet | 207 | 11 | Running | – |
| 27 | 25 | 96 | Daniel Suarez | Toyota | 207 | 10 | Running | 1 |
| 28 | 29 | 77 | JJ Yeley | Chevrolet | 207 | 0 | Running | – |
| 29 | 30 | 51 | Joey Gase | Ford | 207 | 0 | Running | – |
| 30 | 11 | 42 | Matt Kenseth | Chevrolet | 206 | 9 | Running | – |
| 31 | 22 | 41 | Cole Custer # | Ford | 206 | 6 | Running | – |
| 32 | 28 | 27 | Gray Gaulding | Ford | 206 | 5 | Running | – |
| 33 | 33 | 66 | Timmy Hill | Toyota | 204 | 0 | Running | – |
| 34 | 36 | 53 | Garrett Smithley # | Chevrolet | 204 | 3 | Running | – |
| 35 | 12 | 38 | John H. Nemechek # | Ford | 202 | 2 | Running | – |
| 36 | 38 | 78 | BJ McLeod | Chevrolet | 202 | 0 | Running | – |
| 37 | 27 | 15 | Brennan Poole # | Chevrolet | 201 | 1 | Transmission | 1 |
| 38 | 17 | 9 | Chase Elliott | Chevrolet | 200 | 14 | Accident | 28 |
| 39 | 1 | 37 | Ryan Preece | Chevrolet | 69 | 2 | Engine | – |
Time of Race: 2 Hrs, 42 Mins, 23 Secs.
Average Speed: 104.984 MPH
Margin of Victory: Under Caution
Stage 1 Top 10: 14, 19, 12, 88, 22, 10, 9, 11, 42, 37
Stage 2 Top 10: 14, 9, 19, 20, 4, 24, 11, 88, 22, 21
Race Comments: Denny Hamlin won the Toyota 500 at Darlington Raceway, his 39th victory in the NASCAR Cup Series. Prior to the start of the race, the following vehicle(s) dropped to the rear of the field under penalty for the reasons indicated: Nos. 78, 32 (Multiple Inspection Failures), Nos. 27, 77 (Driver Change), No. 20 (Unapproved Adjustments). Race Recap
Caution Flags: 11 for 54 laps; Laps: 4-7 (#38, 42 Incident Turn 4 [78]); 12-14 (#38 Incident Backstretch [None]); 27-30 (Competition Caution [38]); 62-68 (Stage 1 Conclusion [77]); 73-76 (#34, 17 Incident Turn 2 [00]); 83-86 (#47 Incident Turn 2 [15]); 109-112 (#41 Incident Turn 2 [77]); 127-132 (Stage 2 Conclusion [51]); 180-186 (#42 Spin Turn 2 [18]); 196-199 (#14 Incident Turn 3 [12]); 202-208 (#18, 9 Incident Fronstretch [17]).
Lead Changes: 17 among 13 drivers; R. Preece 0; T. Dillon 1-8; J. Logano 9-27; B. Wallace 28-30; C. Bowyer 31-83; M. Truex Jr. 84-99; K. Harvick 100-109; *. Suarez 110; C. Bowyer 111-128; R. Newman 129-133; E. Jones 134-160; C. Elliott 161-175; B. Keselowski 176-181; B. Poole # 182; C. Elliott 183-190; B. Keselowski 191; C. Elliott 192-196; D. Hamlin 197-208.
