| Fin | Str | Car | Driver | Make | Laps | Pts | Status | Laps Led |
| 1 | 2 | 42 | Kyle Larson (P) | Chevrolet | 400 | 57 | Running | 154 |
| 2 | 3 | 19 | Martin Truex Jr. (P) | Toyota | 400 | 54 | Running | 15 |
| 3 | 12 | 88 | Alex Bowman (P) | Chevrolet | 400 | 44 | Running | 0 |
| 4 | 4 | 4 | Kevin Harvick (P) | Ford | 400 | 46 | Running | 0 |
| 5 | 1 | 11 | Denny Hamlin (P) | Toyota | 400 | 50 | Running | 218 |
| 6 | 18 | 18 | Kyle Busch (P) | Toyota | 400 | 34 | Running | 0 |
| 7 | 20 | 95 | Matt DiBenedetto | Toyota | 400 | 30 | Running | 0 |
| 8 | 11 | 48 | Jimmie Johnson | Chevrolet | 400 | 39 | Running | 1 |
| 9 | 9 | 1 | Kurt Busch | Chevrolet | 399 | 28 | Running | 3 |
| 10 | 17 | 14 | Clint Bowyer (P) | Ford | 399 | 28 | Running | 0 |
| 11 | 16 | 2 | Brad Keselowski (P) | Ford | 399 | 28 | Running | 0 |
| 12 | 13 | 21 | Paul Menard | Ford | 398 | 25 | Running | 6 |
| 13 | 6 | 24 | William Byron (P) | Chevrolet | 398 | 31 | Running | 1 |
| 14 | 15 | 41 | Daniel Suarez | Ford | 398 | 23 | Running | 1 |
| 15 | 8 | 20 | Erik Jones | Toyota | 398 | 28 | Running | 0 |
| 16 | 19 | 17 | Ricky Stenhouse Jr. | Ford | 398 | 21 | Running | 0 |
| 17 | 7 | 10 | Aric Almirola | Ford | 398 | 20 | Running | 0 |
| 18 | 27 | 3 | Austin Dillon | Chevrolet | 398 | 19 | Running | 0 |
| 19 | 32 | 47 | Ryan Preece # | Chevrolet | 396 | 18 | Running | 0 |
| 20 | 26 | 43 | Bubba Wallace | Chevrolet | 395 | 17 | Running | 0 |
| 21 | 31 | 8 | Daniel Hemric # | Chevrolet | 394 | 16 | Running | 0 |
| 22 | 24 | 6 | Ryan Newman | Ford | 393 | 15 | Running | 0 |
| 23 | 25 | 13 | Ty Dillon | Chevrolet | 393 | 14 | Running | 1 |
| 24 | 28 | 34 | Michael McDowell | Ford | 391 | 13 | Running | 0 |
| 25 | 23 | 36 | Matt Tifft # | Ford | 390 | 12 | Running | 0 |
| 26 | 30 | 00 | Landon Cassill | Chevrolet | 389 | 0 | Running | 0 |
| 27 | 21 | 38 | David Ragan | Ford | 388 | 10 | Running | 0 |
| 28 | 29 | 32 | Corey LaJoie | Ford | 385 | 9 | Running | 0 |
| 29 | 33 | 51 | BJ McLeod | Chevrolet | 382 | 0 | Running | 0 |
| 30 | 36 | 27 | Joe Nemechek | Chevrolet | 381 | 0 | Running | 0 |
| 31 | 34 | 15 | Ross Chastain | Chevrolet | 380 | 0 | Running | 0 |
| 32 | 35 | 52 | JJ Yeley | Ford | 380 | 0 | Running | 0 |
| 33 | 37 | 54 | Garrett Smithley | Ford | 377 | 0 | Running | 0 |
| 34 | 14 | 22 | Joey Logano (P) | Ford | 375 | 3 | Running | 0 |
| 35 | 10 | 12 | Ryan Blaney (P) | Ford | 297 | 6 | Suspension | 0 |
| 36 | 22 | 37 | Chris Buescher | Chevrolet | 232 | 1 | Engine | 0 |
| 37 | 38 | 77 | Reed Sorenson | Chevrolet | 180 | 1 | Handling | 0 |
| 38 | 5 | 9 | Chase Elliott (P) | Chevrolet | 8 | 1 | Engine | 0 |
Time of Race: 2 Hrs, 56 Mins, 49 Secs.
Average Speed: 135.734 MPH
Margin of Victory: 1.578 Seconds
Stage 1 Top 10: 11, 19, 42, 24, 4, 88, 48, 18, 20, 12
Stage 2 Top 10: 19, 42, 11, 4, 48, 88, 20, 12, 2, 14
Race Comments: Kyle Larson won the Drydene 400 at Dover International Speedway, his sixth victory in the Monster Energy NASCAR Cup Series. Prior to the start of the race, no vehicles dropped to the rear of the field under penalty.
Caution Flags: 3 for 17 laps; Laps: 9-12 (Debris [None]); 122-127 (Stage 1 Conclusion [95]); 242-248 (Stage 2 Conclusion [21]).
Lead Changes: 14 among 9 drivers; D. Hamlin (P) 1-11; K. Larson (P) 12; D. Hamlin (P) 13-75; W. Byron (P) 76; J. Johnson 77; K. Busch 78-80; D. Suarez 81; T. Dillon 82; D. Hamlin (P) 83-183; K. Larson (P) 184-185; D. Hamlin (P) 186-228; M. Truex Jr. (P) 229-243; K. Larson (P) 244-321; P. Menard 322-327; K. Larson (P) 328-400.
