| Fin | Str | Car | Driver | Make | Laps | Pts | Status | Laps Led |
| 1 | 1 | 18 | Kyle Busch | Toyota | 400 | 70 | Running | 377 |
| 2 | 15 | 78 | Martin Truex Jr. | Toyota | 400 | 54 | Running | – |
| 3 | 3 | 11 | Denny Hamlin | Toyota | 400 | 49 | Running | 9 |
| 4 | 5 | 2 | Brad Keselowski | Ford | 400 | 41 | Running | 2 |
| 5 | 23 | 48 | Jimmie Johnson | Chevrolet | 400 | 41 | Running | – |
| 6 | 7 | 1 | Jamie McMurray | Chevrolet | 400 | 37 | Running | – |
| 7 | 11 | 42 | Kyle Larson | Chevrolet | 400 | 46 | Running | – |
| 8 | 16 | 41 | Kurt Busch | Ford | 400 | 36 | Running | – |
| 9 | 27 | 88 | Alex Bowman | Chevrolet | 400 | 28 | Running | – |
| 10 | 13 | 17 | Ricky Stenhouse Jr. | Ford | 399 | 31 | Running | – |
| 11 | 22 | 9 | Chase Elliott | Chevrolet | 399 | 30 | Running | – |
| 12 | 28 | 14 | Clint Bowyer | Ford | 399 | 35 | Running | – |
| 13 | 9 | 10 | Aric Almirola | Ford | 399 | 34 | Running | – |
| 14 | 14 | 21 | Paul Menard | Ford | 399 | 23 | Running | – |
| 15 | 10 | 19 | Daniel Suarez | Toyota | 399 | 22 | Running | – |
| 16 | 24 | 43 | Bubba Wallace | Chevrolet | 399 | 21 | Running | – |
| 17 | 17 | 6 | Matt Kenseth | Ford | 399 | 20 | Running | – |
| 18 | 29 | 34 | Michael McDowell | Ford | 399 | 19 | Running | – |
| 19 | 4 | 20 | Erik Jones | Toyota | 399 | 29 | Running | – |
| 20 | 26 | 95 | Kasey Kahne | Chevrolet | 399 | 21 | Running | – |
| 21 | 20 | 13 | Ty Dillon | Chevrolet | 399 | 16 | Running | – |
| 22 | 2 | 22 | Joey Logano | Ford | 399 | 15 | Running | 12 |
| 23 | 30 | 47 | AJ Allmendinger | Chevrolet | 399 | 14 | Running | – |
| 24 | 25 | 15 | Ross Chastain | Chevrolet | 398 | 0 | Running | – |
| 25 | 19 | 38 | David Ragan | Ford | 396 | 12 | Running | – |
| 26 | 33 | 72 | Corey LaJoie | Chevrolet | 396 | 11 | Running | – |
| 27 | 32 | 96 | Parker Kligerman | Toyota | 394 | 0 | Running | – |
| 28 | 35 | 00 | Landon Cassill | Chevrolet | 394 | 9 | Running | – |
| 29 | 18 | 37 | Chris Buescher | Chevrolet | 394 | 8 | Running | – |
| 30 | 37 | 55 | Jeffrey Earnhardt | Chevrolet | 389 | 7 | Running | – |
| 31 | 34 | 23 | Gray Gaulding | Toyota | 388 | 6 | Running | – |
| 32 | 36 | 66 | Timmy Hill | Toyota | 383 | 0 | Running | – |
| 33 | 38 | 51 | BJ McLeod | Chevrolet | 373 | 0 | Running | – |
| 34 | 12 | 3 | Austin Dillon | Chevrolet | 348 | 3 | Running | – |
| 35 | 6 | 31 | Ryan Newman | Chevrolet | 344 | 5 | Running | – |
| 36 | 8 | 12 | Ryan Blaney | Ford | 278 | 10 | Engine | – |
| 37 | 31 | 32 | Matt DiBenedetto | Ford | 257 | 1 | Oil Leak | – |
| 38 | 40 | 7 | JJ Yeley | Chevrolet | 191 | PE | Fuel Pump | – |
| 39 | 21 | 24 | William Byron | Chevrolet | 139 | 1 | Accident | – |
| 40 | 39 | 4 | Kevin Harvick | Ford | 83 | 1 | Accident | – |
Time of Race: 04 Hrs, 23 Mins, 22 Secs.
Average Speed: 136.692 MPH
Margin of Victory: 3.823 Seconds
Stage 1 Top 10: 18,12,42,78,48,10,14,11,17,20
Stage 2 Top 10: 18,78,42,11,14,10,9,48,31,20
Stage 3 Top 10: 18,20,2,41,1,11,95,78,17,31
Race Comments: Kyle Busch won the Coca-Cola 600 at Charlotte Motor Speedway, his 47th Monster Energy NASCAR Cup Series victory. Prior to the start of the race, the following cars dropped to the rear of the field for the reasons indicated: #00- inspection failure, 43- Unapproved adjustments.
Caution Flags: 11 for 54 laps: Laps: 38-43 (#3 Incident Turn 2 [34]); 85-88 (#4 Incident Turn 3 [15]); 102-107 (Stage 1 Conclusion [32]); 116-119 (#24 Incident Turn 1 [15]); 121-123 (#48, 22,11, 20 Incident Turn 4 [72]); 202-207 (Stage 2 Conclusion [2]); 227-230 (#23 Spin Turn 4 [21]); 260-264 (#37 Incident Turn 4 [34]); 274-277 (#42 Spin Turn 1 [13]); 280-285 (Oil on track from #12 [47]); 302-307 (Stage 3 Conclusion [6]).
Lead Changes: 9 among 4 drivers: Kyle Busch 0; J. Logano 1-4; Kyle Busch 5-85; B. Keselowski 86-87; Kyle Busch 88-158; D. Hamlin 159-165; J. Logano 166-173; Kyle Busch 174-352; D. Hamlin 353-354; Kyle Busch 355-400.
